Cacheu, a small city in northwestern Guinea-Bissau with a population of around 10,000, is historically significant for its Portuguese-built 16th-century fort and role as a major slave trading center in the 17th and 18th centuries. Founded in 1588, it was one of the earliest European settlements in sub-Saharan Africa, situated strategically on the Cacheu River. The town's history is intertwined with European and Afro-European influences, particularly from Portuguese traders and exiles. Today, Cacheu offers access to nearby Tarrafe Natural Park and traditional villages, with transport options including canoe trips to São Domingos and regular connections via road from Bissau.